Whom am I ?
Dr. Perrey's research is concerned with the neurophysiological approach to problems of muscle fatigue
and locomotion. Prof. Perrey is the author of more than 100 publications in peer-review journals, and more than 120 scientific communications in proceedings. He belongs to the Institut Universitaire de France.
My centres of interests
My current researches are in the centre of issues, which have for objectives to identify, quantify and explain mechanisms responsible for changes of the motor function in humans. They integrate a multidisciplinary approach (motor control and physiology) and articulate around two main axes: the adaptative response of energetic metabolism on muscle combining, oxygen uptake, near-infrared and 31P-NMR spectroscopy during various workloads, and the study of neuromuscular properties associated to localized measurements of muscular and cerebral oxygenation in responses to motor stimuli. The proposed research program was developed in three parts these past four years. The first one consists of the study on the metabolic determinants of fatigue. The second part is dealing with the concept of the nervous fatigue, showing how the brain plays a fundamental role in the muscular adjustment at the origin of the production of movement. The third part consists of a theoretical then empirical work allowing connecting the fatigue and its repercussions on the human movement in health and disease. Methodologies involve a state-of-the-art laboratory research to investigate neuromechanics of human movement (force measurement systems: strain gauge, force plate and Biodex ergometer and electrophysiological measurement systems: electromyography, electrostimulation) as well as to explore energetic metabolism adjustment to motor tasks (alveolar oxygen uptake, tissue oxygenation, NMR). During the last four years experimental findings allow to show the importance of the central motor output in determining voluntary (loco)motor performance with (for local and whole-body exercises) and without severe fatigue. A spinal component to the central fatigue involved in the regulation of exercise performance was also showed in several research paradigms. These findings are compatible with the notion of a role for the cortex in the modulation of motor output by the cessation of exercise. Functional investigation of the brain function was more recently developed with electrophysiological and near-infrared spectroscopy signals. The latter enables to study brain function in everyday situations, which involve free movement of subjects ;
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Projects : ERGO-NECK, tDCS (NorDocs)-TOT, ,